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KMID : 0942820070060010010
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Journal of Korean Brain Tumor Society
2007 Volume.6 No. 1 p.10 ~ p.14
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Prognostic implication of chromosomal study for oligodendroglial tumors
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Kwon Yoon-Kwang
Park Seong-Ho
Son Eun-Ik
Kim Eal-Maan
Kim Sang-Pyo
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Abstract
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Objective：This study focused on the clinical outcomes and the potential impact of genetic analysis to predict the clinical outcomes following treatment options including surgery, adjuvant radiotherapy and chemotherapy in patients with oligodendroglial tumors.
Methods： We conducted a retrospective analysis of the medical records of 13 patients who were newly diagnosed with oligodendroglioma and anaplastic oligodendroglioma between 1995 and 2006.
Results：The 13 patients included ten men(77%) and three women(23%). Seven tumors were histologically classified as low-grade oligodendrogliomas(WHO grade II), and the remaining six tumors were classified as anaplastic oligodendrogliomas(grade III). Seizure was the most frequent presenting symptom. All patients were treated surgically. Molecular genetic studies were performed on tumor and blood samples from all patients. LOH for loci on chromosome 1p was detected in all oligodendrogliomas(100%) and four of six anaplastic oligodendrogliomas(67%). LOH in loci from chromosome 19 was found in all oligodendrogliomas(100%) and in five of six anaplastic oligodendrogliomas(83%). One patient with anaplastic oligodendroglioma revealed no loss of 19q. Two patients with anaplastic oligodendroglioma died, one in whom the anaplastic oligodendroglioma retained 19q and the other in whom the anaplastic oligodendroglioma had lost 19q.Those two patients showed a rapid spread of the tumor and no responsiveness to chemotherapy.
Conclusion：Molecular genetic study is a potentially useful way of characterizing the biological features of patients and identifying patients with a high risk of developing oligodendroglial tumors. Oligodendroglial tumors correlate with a high occurrence of loss of heterozygosity(LOH) on chromosomes 1p and 19q. It can be a specific predictor of prognosis of oligodendroglial tumors.
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KEYWORD
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Oligodendroglial tumor, Chromosomal study, Prognosis
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